Cabaletta Bio to Participate in the Jefferies Global Healthcare Conference

Reuters
AstraZeneca's breast cancer drug combination fails in late-stage trial
Triple-negative breast cancer remains one of the most challenging forms of disease to treat due to the lack of known actionable biomarker targets, and chemotherapy-based regimens continue to be the mainstay of treatment, AstraZeneca said. The trial, known as CAPItello-290, was testing whether the drug combination improved overall survival in patients with inoperable or metastatic triple-negative breast cancer versus the older and cheaper chemotherapy agent, paclitaxel, in combination with a placebo.
The New York Times
Doctors Test Obesity Drugs’ Limits
Lesa Walton suffered for years with rheumatoid arthritis. “It was awful,” said Walton, 57, who lives in Wenatchee, Washington. “I kept getting sicker and sicker.” She also had high blood pressure, and she was obese. Doctors told her to diet and exercise, which she did, to no avail. Sign up for The Morning newsletter from the New York Times Then she found a doctor who prescribed Wegovy, one of the new obesity drugs. Not only did she lose more than 50 pounds, she said; her arthritis also cleared,
Reuters
US FDA puts Zentalis' cancer drug studies on partial hold after patient deaths
Shares of the drug developer slumped about 26% to $6.22 in early trading. The drug candidate, azenosertib, was being tested against solid tumors in an early-stage study and in patients with a type of ovarian and uterine cancer in two mid-stage studies. "We don't think this is the end for azenosertib," Oppenheimer analyst Matthew Biegler said, adding that the hold is resolvable with enhanced patient monitoring and preventatives.
The Canadian Press
Wife of Toronto gunman says two victims allegedly defrauded family of life savings
TORONTO — The gunman in a fatal Toronto shooting believed the two victims had defrauded his family, his wife said, as court records indicate the family was suing the pair after losing more than a million dollars in an alleged investment scam.
HuffPost
CNN Data Reporter 'Speechless' By New Donald Trump-Joe Biden Poll: 'Holy Cow, Folks!'
Harry Enten said it could point to "a historic moment" in American politics.
The Canadian Press
Plastic surgeon charged in death of wife who went into cardiac arrest while he worked on her
PENSACOLA, Fla. (AP) — A plastic surgeon in the Florida Panhandle was charged with his wife's death after she suffered a cardiac arrest and died days after he performed after-hours procedures on her in his clinic last year, authorities said.
Hello!
Duchess Sophie’s new figure-hugging dress is so va va voom
Sophie, Duchess of Edinburgh looked amazing at an event at the Peninsula London with Prince Edward, wearing a new Roland Mouret dress and high heels.
The Daily Beast
Roger Stone Caught on Tape Discussing Trump’s Plan to Challenge 2024 Election
Roger Stone, a longtime Republican operative who served as an adviser to Donald Trump, was secretly recorded at Mar-a-Lago spilling the beans on the former president’s strategy to challenge the results of the 2024 election should he lose again. The self-described “dirty trickster” of right-wing politics unknowingly divulged the plan to liberal reporters Lauren Windsor and Ally Sammarco, who posed as Trump fans and covertly videotaped him at a “Catholics Prayer for Trump” event on March 19. The r
HuffPost
'This Is So Pathetic': Lindsey Graham Torched For Reality-Defying Trump Defense
The South Carolina senator trotted out an upside-down version of events on Fox News.
The Independent
Former aide insists Melania’s marriage to Trump is just a ‘mirage’ dreamed up by TV producers
‘He needed a woman who looked & played the part & let him be the star,’ the Melania confidant said of Donald Trump
Global News
Deceased in Toronto commercial building shooting identified
The man and woman fatally shot inside a Don Mills commercial building Monday have been identified as Arash Missaghi and Samira Yousefi. As Catherine McDonald reports, Missaghi faced a lengthy history of lawsuits over alleged mortgage frauds and both were recently named in a civil lawsuit over an alleged mortgage fraud.
The Daily Beast
Trump Bungles His Mockery of Biden Over ‘Clean Fake’ Videos
Donald Trump once again shot himself in the foot while trying to mock President Joe Biden’s cognitive abilities, this time making up a term for the selectively edited videos that conservatives have peddled to portray Biden as feeble.During a campaign rally in Wisconsin on Tuesday, the former president brought up viral clips of Biden that have flooded right-wing media and Trump’s social media feed in recent weeks. The videos, which supposedly show the president “freezing up” or wandering off, hav
FTW Outdoors
Moose chased by bear stops to look back; ‘You still coming?’
A wildlife biologist saw a moose and decided to take a short video. “It ended up being a better video than I expected,” Wes Larson said.
CNN
Israel warns of prospect of ‘all-out war’ after Hezbollah publishes video of military, civilian sites
Israel’s Foreign Minister slammed the Lebanese militant group after it published a 9-minute drone video showing Israeli military and civilian locations in several Israeli cities.
Moneywise
Kevin O'Leary explains why restaurants are shuttering across America — and why more will follow
An “upscale McDonald's” is a luxury many can't afford, he says.
BuzzFeed
This 26-Year-Old Refused To Buy His Girlfriend A $10,000 Engagement Ring Because She's Not "Worth It"
"I’ve always known marriage is super important to her, but I didn’t realize she’d insist on a diamond ring."
CNN
The Supreme Court’s approach on ‘history and tradition’ is irking Amy Coney Barrett
On a Supreme Court where the conservative supermajority increasingly leans on history as a guide, a dispute may be simmering over how many modern cases can be resolved by looking to the nation’s past.
People
Therapist Dying of Cancer Leaves Viral Goodbye Message: 'I Was Completely Shocked,' Husband Says (Exclusive)
Sarah Mandel lived with transparency in "both the good and bad" and "let herself feel," her brother says
The Hill
Trump’s bid to oust Good ends in nail-biter: 5 takeaways from Tuesday’s primaries
A stunningly tight race in Virginia was among the highlights of Tuesday night’s elections, which also included contests in Georgia and Oklahoma. Observers had been closely monitoring the GOP primary for Rep. Bob Good’s seat in Virginia’s 5th Congressional District. The contest had boiled over into one of the most tumultuous primaries of the cycle…
Futurism
NASA Rover Discovers Strange Stones, Never Before Seen on Mars
NASA's Perseverance Mars rover took a shortcut to steer clear of a path riddled with boulders — and then stumbled into a field full of them that scientists have never seen before. On its fourth campaign since landing three years ago, the tireless rover roamed its way through a dried-up river channel called Neretva Vallis […]

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Cabaletta Bio to Participate in the Jefferies Global Healthcare Conference

Latest Stories

AstraZeneca's breast cancer drug combination fails in late-stage trial

Doctors Test Obesity Drugs’ Limits

US FDA puts Zentalis' cancer drug studies on partial hold after patient deaths

Wife of Toronto gunman says two victims allegedly defrauded family of life savings

CNN Data Reporter 'Speechless' By New Donald Trump-Joe Biden Poll: 'Holy Cow, Folks!'

Plastic surgeon charged in death of wife who went into cardiac arrest while he worked on her

Duchess Sophie’s new figure-hugging dress is so va va voom

Roger Stone Caught on Tape Discussing Trump’s Plan to Challenge 2024 Election

'This Is So Pathetic': Lindsey Graham Torched For Reality-Defying Trump Defense

Former aide insists Melania’s marriage to Trump is just a ‘mirage’ dreamed up by TV producers

Deceased in Toronto commercial building shooting identified

Trump Bungles His Mockery of Biden Over ‘Clean Fake’ Videos

Moose chased by bear stops to look back; ‘You still coming?’

Israel warns of prospect of ‘all-out war’ after Hezbollah publishes video of military, civilian sites

Kevin O'Leary explains why restaurants are shuttering across America — and why more will follow

This 26-Year-Old Refused To Buy His Girlfriend A $10,000 Engagement Ring Because She's Not "Worth It"

The Supreme Court’s approach on ‘history and tradition’ is irking Amy Coney Barrett

Therapist Dying of Cancer Leaves Viral Goodbye Message: 'I Was Completely Shocked,' Husband Says (Exclusive)

Trump’s bid to oust Good ends in nail-biter: 5 takeaways from Tuesday’s primaries

NASA Rover Discovers Strange Stones, Never Before Seen on Mars