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Boston Scientific (BSX) Upbeat on Results of EVOLVE Study

Zacks Equity Research

Boston Scientific Corporation BSX recently announced the primary endpoint results from the EVOLVE Short dual antiplatelet therapy (“DAPT”) clinical trial. The company claims it to be the first DAPT study in patients at high risk for bleeding. The study was conducted to observe the safety of a shortened duration of DAPT in such patients.

The results of the study, presented at the clinical science session at the 31st Transcatheter Cardiovascular Therapeutics (“TCT”) (the annual scientific symposium of the Cardiovascular Research Foundation) in San Francisco, confirmed that a three-month regimen of DAPT yields similar results to a 12-month or longer treatment in patients with an increased risk of bleeding after being treated with the SYNERGY Bioabsorbable Polymer (“BP”) Stent.

With the publication of the positive outcome of this study, the company aims to fortify its presence in the global percutaneous coronary intervention market.

 



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The Study in Detail

Patients selected for this study were initially implanted with at least one SYNERGY BP stent and considered at high risk for bleeding after fulfilling at least one of the criteria such as the age of 75 or older, with potential risk of long-term DAPT. Objectives of the study were to assess the death rate or myocardial infarction (MI), and the rate of stent thrombosis between three and 15 months, which were successful.

Out of 2009 patients enrolled for the study, 1487 were eligible to discontinue the dual-antiplatelet therapy after three months. Patients treated with a short DAPT regimen were seen to exhibit similar results as patients treated with 12-month DAPT. Also, the rate of stent thrombosis between three and 15 months in the patients treated with three-month DAPT was much lower than the expectations of the study.

Significance of the Study

Per the medical fraternity participating in the study, the positive outcome of the study will likely inform physicians how to shorten the duration of DAPT to the bleeding risk of patients. Earlier, the mandatory period of DAPT, following implantation of current-generation drug-eluting stent platforms, was unknown.

Based on the positive outcomes, the company is looking forward to submitting these data to supervisory authorities to get approvals for the use of stent in patients at high risk of bleeding.

Industry Prospects

Per a report by Market Research Future, the global percutaneous coronary intervention market is expected to see a CAGR of 7.1%, reaching $15,205.4 million till 2023. The key factors driving the market are the rising occurrence of cardiac diseases, the increasing preferences for minimally invasive procedures and growing elderly population that are more susceptible to these diseases.

Given the huge potential in this market, the positive outcome of the study has come at the right time.

Recent Developments

Of late, the company has made certain developments with respect to its cardiovascular care.

Boston Scientific has obtained CE Mark for the SYNERGY MEGATRON BP Stent, the latest within the SYNERGY family of products, in September, 2019.

The company announced the continual access to the Eluvia Drug-Eluting Vascular Stent (DES) System in August after the FDA issued a guidance to clinicians regarding the benefit-risk profile of peripheral paclitaxel devices proposed for the treatment of peripheral artery disease (PAD).

Price Performance

The company’s shares have risen 3.4% in the past year against the industry’s decline of 2.6%. However, the S&P 500 index inched up 0.2% during the same period.

Zacks Rank & Key Picks

Currently, Boston Scientific carries a Zacks Rank #3 (Hold). Some better-ranked stocks from the broader medical space are Valeritas Holdings, Inc VLRX, GW Pharmaceuticals PLC GWPH and Neurotrope, Inc NTRP.

Valeritas, currently carrying a Zacks Rank #2 (Buy), has projected third-quarter 2019 earnings growth rate of 40.5%. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

GW Pharmaceuticals estimates third-quarter earnings growth rate to be 65.5%. It currently flaunts a Zacks Rank #1.

Neurotrope, with a Zacks Rank #2, has projected third-quarter earnings growth rate of 31.9%.

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