The midfielder injured his ankle during a pre-season friendly with Chelsea in August and he made his comeback last week against Norwich.
Partey started on the bench for that game - coming on with 30 minutes to go - but is in from the outset in what looks an attacking side at Turf Moor.
The Ghanaian will play a key role for Arsenal this season and the club were wary about rushing him back.
“He is there. He has been training in and out this week. His load had to be managed because he was in the early stages of the injury and what he had,” said Arteta.
“But he is pushing everybody, as he always does, and he wants to be involved. We will make the decision for the weekend as to what is best for him.”
Aaron Ramsdale keeps his place over Bernd Leno in goal, while the defence in front of him is unchanged after keeping the club’s first league clean sheet of the season against Norwich.
Arsenal starting XI: Ramsdale, Tomiyasu, White, Gabriel, Tierney, Partey, Smith-Rowe, Pepe, Odegaard, Saka, Aubameyang.
Saturday 3.00pm GMT
Referee: Anthony Taylor
Arsenal squad from: Leno, Ramsdale, Okonkwo; Cedric, Chambers, Gabriel, Kolasinac, Mari, Tavares, Tierney, Tomiyasu, White; Lokonga, Maitland-Niles, Odegaard, Partey, Saka, Smith Rowe; Aubameyang, Balogun, Lacazette, Martinelli, Nketiah and Pepe.
Injured: Elneny (hamstring) and Holding (knee)