Devin Ryan, JMP Securities Analyst joins the On the Move panel to discuss the latest Goldman Sachs bank earnings.
Devin Ryan, JMP Securities Analyst joins the On the Move panel to discuss the latest Goldman Sachs bank earnings.
Professor Neil Ferguson said decisions on whether to loosen household mixing rules over the festive period would be a “political judgment”.
New Delhi [India], October 24 (ANI): Defence Minister Rajnath Singh on Saturday departed for Darjeeling from the national capital on a two-day visit to West Bengal and Sikkim during which he will be visiting forward areas and interacting with the troops.
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Opposition supporters contest results showing President Alpha Condé, 82, is set for re-election.
Snowy weather was seen in some parts of Jefferson county, Colorado, less than 80 miles away from where the East Troublesome Fire is raging.Hopes are rising as heavy snow was forecast to hit Colorado this weekend.As of the early hours of October 24, the East Troublesome Fire had burned 188,079 acres and was 4% contained. Credit: @jcosrangerjason via Storyful
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* First and only chemoprotective therapy in clinical development that utilizes a biomarker strategy designed to protect patients with p53-mutated cancers from chemotherapy-induced toxicities and side effects * Treatment with ALRN-6924 prior to topotecan administration resulted in a protective effect against severe chemotherapy-induced bone marrow toxicities in patients with p53-mutated small cell lung cancer (SCLC) * Robust and clinically meaningful protection against toxicities observed with 0.3 mg/kg dose of ALRN-6924 * Aileron to host conference call and webcast on Monday, October 26, 2020 at 8:30 a.m. ET to discuss the data and its clinical development strategy to expand chemoprotection to multiple p53-mutated cancers and chemotherapiesWATERTOWN, Mass., Oct. 24, 2020 (GLOBE NEWSWIRE) -- Aileron Therapeutics (Nasdaq: ALRN) today announced new positive clinical data from its ongoing Phase 1b trial demonstrating clinical proof of concept that treatment with ALRN-6924 prior to second-line topotecan administration resulted in a protective effect against severe anemia, thrombocytopenia and neutropenia in patients with p53-mutated small cell lung cancer (SCLC). The results are being featured today in a late-breaking poster presentation entitled, “Prevention of Chemotherapy-induced Myelosuppression in SCLC Patients Treated with Dual MDM2/MDMX Inhibitor ALRN-6924” (online here) at the 32nd EORTC-NCI-AACR Annual (ENA 2020) Symposium on Molecular Targets and Cancer Therapeutics.Chemotherapy, the backbone of treatment for millions of cancer patients, is unselective, meaning it cannot distinguish between cancer cells and healthy cells. As a result, chemotherapy destroys both cancer cells and rapidly dividing healthy cells, such as bone marrow cells, hair follicle cells and skin cells, among others. ALRN-6924 is the first and only chemoprotective therapy in clinical development that utilizes a biomarker strategy. Specifically, ALRN-6924 is a cell-permeating peptide drug designed to work intracellularly, activating wild-type p53 to selectively shield healthy cells from chemotherapy in patients who harbor p53-mutant tumors, approximately 50% of all cancer patients, without interrupting chemotherapy’s targeting of cancer cells.“These proof-of-concept results for ALRN-6924 bring us a major step closer toward our goal of creating a new paradigm of proactive prevention of chemotherapy-induced side effects to address a significant unmet need among cancer patients,” said Manuel Aivado, M.D., Ph.D., President and CEO of Aileron. “As a medical oncologist, I appreciate that physicians need assurance that a chemoprotective agent will not reduce the efficacy of chemotherapy or promote tumor growth. Designed to shield only healthy, non-p53-mutated cells and leave p53-mutated cancer cells fully vulnerable to chemotherapy, we believe ALRN-6924 provides that assurance. With ALRN-6924, we believe we have the potential to ultimately bring chemoprotection to patients across a broad set of cancer types, improving their quality of life and enhancing their anti-cancer response to chemotherapy.”Dr. Vojislav Vukovic, M.D., Ph.D., Chief Medical Officer at Aileron, commented, “We are extremely pleased to have achieved clinical proof of concept in our ongoing Phase 1b trial. ALRN-6924 has demonstrated the ability to protect very sick patients with SCLC against severe and life-threatening toxicities and side effects that are associated with a chemotherapy that is known to be highly toxic to the bone marrow. Importantly, we now have validation to expand clinical development into other types of p53-mutated cancers and chemotherapies and pursue our long-term vision to bring chemoprotection to all patients with p53-mutated cancers regardless of cancer type or chemotherapy.”Data HighlightsAs of August 31, 2020, the data cut-off for this data presentation, a total of 26 adult patients were enrolled in the dose optimization part of the ALRN-6924 Phase 1b trial, evaluating treatment with ALRN-6924 given 24 hours prior to chemotherapy. 18 patients were enrolled across three ALRN-6924 dose levels (1.2 mg/kg, 0.6 mg/kg and 0.3 mg/kg) and an additional eight (8) patients were enrolled in a 0.3 mg/kg expansion cohort. 25 of these patients were evaluable per the trial protocol. ALRN-6924 was administered 24 hours before each dose of topotecan. Topotecan (1.5 mg/m2) was administered on days 1 through 5 of every 21-day treatment cycle. In the trial, toxicities were evaluated using the National Cancer Institute’s (NCI) Common Terminology Criteria for Adverse Events (CTCAE). Per the Phase 1b trial protocol, patients were not permitted to receive prophylactic G-CSF treatment in cycle 1.Across all ALRN-6924 dose levels, Grade 3/4 anemia, Grade 3/4 thrombocytopenia and Grade 4 neutropenia (defined as <500/µL) were limited to 24%, 36% and 48% of patients, respectively. In the topotecan plus placebo arm of a recent third-party randomized Phase 2 trial in SCLC patients receiving topotecan (n=28), Grade 3/4 anemia, Grade 3/4 thrombocytopenia and Grade 4 neutropenia were reported in 63%, 70% and 76% of patients, respectively (Hart et al., ASCO 2019). In the ALRN-6924 trial, while chemoprotection effects were observed across all ALRN-6924 dose levels, the 0.3 mg/kg dose level showed the most robust chemoprotection results, with Grade 3/4 anemia, Grade 3/4 thrombocytopenia and Grade 4 neutropenia limited to 21%, 36% and 43% of patients, respectively. Additionally, none of the patients on ALRN-6924 experienced febrile neutropenia. In the topotecan plus placebo arm of the recent third-party randomized Phase 2 trial in SCLC patients receiving topotecan (n=29), febrile neutropenia was observed in 17% of patients (Hart et al., ASCO 2019). None of the patients treated at the 0.3 mg/kg ALRN-6924 dose level had hematological serious adverse events (SAEs) and only one patient (7%) received one red blood cell transfusion and one platelet transfusion1. In the topotecan plus placebo arm of the recent third-party randomized Phase 2 trial, 41% and 31% of SCLC patients received red blood cell and platelet transfusions, respectively (Hart et al., ASCO 2019). At the 0.3 mg/kg ALRN-6924 dose level, no patients required erythropoiesis-stimulating agents, and seven patients (50%) required G-CSF treatment._____________________ 1 Finding followed EORTC-NCI-AACR Symposium Late-Breaking Abstract submission. ALRN-6924 (given 24h prior to chemotherapy) Phase 1b Trial Bone Marrow-Related Key Toxicity Findings Adverse Events (AEs)* NCI CTCAE ≥ Grade 3 Third Party Randomized Phase 2 Trial in SCLC Historical Control‡ ToxicityALRN-6924 0.3 mg/kg + Topotecan N (%) N=14ALRN-6924 (All Dose Levels) Topotecan N (%) N=25 Placebo \+ Topotecan N (%) N=28 All AEs13 (93)24 (96)27 (96) Anemia3 (21)6 (24)17 (61) Thrombocytopenia5 (36)9 (36)16 (57) Neutropenia11 (79)22 (88)24 (86) Febrile Neutropenia005 (17) † Neutropenia Grade 46 (43)**12 (48)**21 (76) *AEs based on laboratory values, as applicable **For cycle 1 and for all treatment cycles ‡ Hart et al. ASCO 2019 † Febrile neutropenia reported for 29 patients“Chemotherapy-induced toxicities historically have been viewed by the medical community as an unfortunate yet unavoidable reality associated with effective chemotherapeutics. With therapeutic advancements like ALRN-6924, I believe there is a potential to dramatically evolve that mindset,” said Bojan Zaric, M.D., Ph.D., Head of Clinical Research, Head of Lung Cancer Clinic, Institute for Pulmonary Diseases of Vojvodina, Serbia, and Principal Investigator of the ALRN-6924 Phase 1b trial.Dr. Zaric continued, “These Phase 1b data provide early yet important insights into ALRN-6924’s unique activity among chemoprotective agents in development, as well as potential advantages over the current standard of care therapies to address bone marrow toxicities. The findings suggest a strong potential for ALRN-6924 to protect patients undergoing chemotherapy against severe anemia, thrombocytopenia and neutropenia.”Enrollment in the dose optimization part of the Phase 1b trial (ALRN-6924 administered 24 hours before topotecan) is complete, and monitoring is ongoing with four of the evaluable patients continuing treatment past the data cut-off date. Upcoming MilestonesAileron continues to enroll patients in a schedule optimization part of the Phase 1b trial intended to determine whether ALRN-6924 given six hours prior to topotecan (“6h-schedule part”) could be an alternative dosing schedule that could provide patients and healthcare providers with additional flexibility of when to administer ALRN-6924 before topotecan. The company expects to report final data from the Phase 1b trial, including data from the 6h-schedule part, in the first quarter of 2021.In addition, in the fourth quarter of 2020, Aileron plans to initiate a clinical study of ALRN-6924 in healthy volunteers to characterize the time to onset, and the magnitude and duration of cell cycle arrest in human bone marrow relative to ALRN-6924 administration. Subject to the results of the healthy volunteer study and the final data from the Phase 1b trial, Aileron expects to initiate a non-small cell lung cancer program beginning with a Phase 1b trial in the fourth quarter of 2021 and a development program in a gastrointestinal cancer indication at a later point in time. Aileron does not currently plan to conduct additional development of ALRN-6924 in patients with SCLC.“We designed a robust Phase 1b trial to enable us to evaluate multiple dose levels and schedules of ALRN-6924,” said Dr. Vukovic. “We anticipate garnering additional insights from the alternative six-hour dosing schedule part of the Phase 1b SCLC trial and the healthy volunteer study that could provide a strong foundation for regulatory discussions around a registration program for ALRN-6924 in non-small cell lung cancer patients who are receiving platinum-based chemotherapy.”Conference Call and WebcastAileron will host a conference call and webcast on Monday, Oct. 26, 2020 at 8:30 a.m. ET to discuss the Phase 1b data and the company’s clinical development strategy to expand its chemoprotection research to multiple p53-mutated cancers and chemotherapies. To access the conference call, investors are invited to dial 877-705-6003 (domestic) or +1 201-493-6725 (international). The conference ID number is 13712133. A live audio webcast can be accessed by visiting the investor relations section of Aileron’s website at https://investors.aileronrx.com/events-presentations. The webcast will be archived on Aileron’s site for one year.How ALRN-6924 Is Designed to Protect Healthy Cells from Chemotherapy ALRN-6924 is being developed by Aileron as a novel chemoprotective medicine to selectively protect healthy cells in patients with cancers that harbor p53 mutations to reduce or eliminate chemotherapy-induced side effects.Chemotherapy preferentially acts on cells that are cycling or undergoing the process of cell division. In cancer cells, the cell cycle is unchecked, which leads to uncontrolled cell proliferation, a hallmark of cancer. Certain types of healthy cells also naturally need to cycle, such as bone marrow cells, hair follicle cells, skin cells, and cells lining the oral cavity and the gastrointestinal tract. As a result, chemotherapy targets and kills both cycling healthy cells and cycling cancer cells. This, in turn, can lead to a spectrum of chemotherapy-induced side effects, from unpleasant to life-threatening and fatal.ALRN-6924, an investigational first-in-class MDM2/MDMX dual inhibitor, is administered prior to chemotherapy to patients with p53-mutant cancers. ALRN-6924 is designed to activate normal p53 protein in patients’ healthy cells, temporarily and reversibly pausing cell cycling to selectively shield the patients’ healthy cells from chemotherapy. The protection is limited to healthy cells, as ALRN-6924 cannot work in p53-mutated cancer cells given that p53 has lost its function in those cells. Therefore, cancer cells continue to cycle uninterrupted and remain fully susceptible to destruction by chemotherapy.About Aileron TherapeuticsAt Aileron, we are focused on transforming the experience of chemotherapy for cancer patients, enabling them to fight cancer without the fear or burden of chemotherapy-induced side effects. ALRN-6924, our first-in-class MDM2/MDMX dual inhibitor activating p53, is the only reported therapeutic agent in clinical development to employ a biomarker strategy, in which we exclusively focus on treating patients with p53-mutated cancers. With this unique, targeted strategy, ALRN-6924 is designed to protect multiple healthy cell types throughout the body from chemotherapy while chemotherapy continues to destroy cancer cells.In addition to potentially reducing or eliminating multiple side effects, ALRN-6924 may also improve patients’ quality of life and help them better tolerate chemotherapy, potentially allowing patients to complete their treatment without dose reductions or delays. Our long-term vision is to bring chemoprotection to patients with p53-mutated cancers – approximately 50% of cancer patients – regardless of cancer type or chemotherapy. Visit us at aileronrx.com to learn more.Forward-Looking Statements Statements in this press release about Aileron's future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements about the Company’s strategy and clinical development plans. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including whether Aileron’s cash resources will be sufficient to fund its continuing operations for the periods anticipated; whether the Company will obtain sufficient cash resources to conduct its planned clinical trials; whether results obtained in clinical trials will be indicative of results obtained in future clinical trials; whether third party data would be indicative of the data that would be obtained in a randomized, head-to-head clinical trial; whether Aileron’s product candidates will advance through the clinical trial process on a timely basis, or at all; whether the results of such trials will be accepted by and warrant submission for approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies; whether Aileron's product candidates will receive approval from regulatory agencies on a timely basis or at all; whether, if product candidates obtain approval, they will be successfully distributed and marketed; what impact the coronavirus pandemic may have on the timing of our clinical development, clinical supply and our operations; and other factors discussed in the "Risk Factors" section of Aileron's quarterly report on Form 10-Q for the period ended June 30, 2020, filed on August 5, 2020, and risks described in other filings that Aileron may make with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Aileron specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise.Investor Contacts: Media Contact: Richard Wanstall, SVP Chief Financial Officer Liz Melone Aileron Therapeutics 617-256-6622 617-995-2822 email@example.com firstname.lastname@example.org Hans C. Vitzthum LifeSci Advisors, LLC. email@example.com
Caprolactam Market Research Report by Application (Films, Nylon 6 Engineering Plastics, and Nylon 6 Fibers) - Global Forecast to 2025 - Cumulative Impact of COVID-19 The Global Caprolactam Market is expected to grow from USD 13,243.New York, Oct. 24, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Caprolactam Market Research Report by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05913720/?utm_source=GNW 78 Million in 2019 to USD 16,086.19 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 3.29%. Market Segmentation & Coverage: This research report categorizes the Caprolactam to forecast the revenues and analyze the trends in each of the following sub-markets: Based on Application, the Caprolactam Market studied across Films, Nylon 6 Engineering Plastics, and Nylon 6 Fibers. The Films further studied across Agricultural Packaging, Food Packaging, and Pharmaceutical Packaging. The Nylon 6 Engineering Plastics further studied across Automotive, Consumer Goods, Electrical & Electronics, Industrial/Machinery, and Wire & Cable. The Nylon 6 Fibers further studied across Carpet Filament, Industrial Filament, Staple Fiber, and Textile Filament. Based on Geography, the Caprolactam Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom. Company Usability Profiles: The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Caprolactam Market including Advansix Inc., Alpek S.A.B. De C.V., BASF SE, Capro Co., China Petrochemical Development Corporation, China Petroleum and Chemical Corporation, DOMO Chemicals, Grupa Azoty, Lanxess AG, Sumitomo Chemical Co., Ltd., The Aquafil Group, Toray Industries, Inc., and UBE Industries, Ltd.. FPNV Positioning Matrix: The FPNV Positioning Matrix evaluates and categorizes the vendors in the Caprolactam Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape. Competitive Strategic Window: The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth. Cumulative Impact of COVID-19: COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market. The report provides insights on the following pointers: 1\. Market Penetration: Provides comprehensive information on the market offered by the key players 2\. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets 3\. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments 4\. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players 5\. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments The report answers questions such as: 1\. What is the market size and forecast of the Global Caprolactam Market? 2\. What are the inhibiting factors and impact of COVID-19 shaping the Global Caprolactam Market during the forecast period? 3\. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Caprolactam Market? 4\. What is the competitive strategic window for opportunities in the Global Caprolactam Market? 5\. What are the technology trends and regulatory frameworks in the Global Caprolactam Market? 6\. What are the modes and strategic moves considered suitable for entering the Global Caprolactam Market? Read the full report: https://www.reportlinker.com/p05913720/?utm_source=GNW About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place. __________________________ CONTACT: Clare: firstname.lastname@example.org US: (339)-368-6001 Intl: +1 339-368-6001
Guardiola said he has not spoken to Aguero about the incident
Kupwara (Jammu and Kashmir) [India], October 24 (ANI): Indian Army troops shot down a Pakistan Army quadcopter along Line of Control (LoC) in Keran sector of Jammu and Kashmir's Kupwara district on Saturday.
The coronavirus pandemic is the main domestic issue as Lithuania holds a parliamentary runoff election Sunday, and the winner will have to tackle a rapidly deteriorating public health sector and high unemployment. In the second round, 68 of the 141 seats in Lithuania's legislative assembly, the Seimas, are up for grabs. The other seats were allotted after the Oct. 11 first round of voting.
Decorate your home with warm colours, fall florals and piles of cosy blankets
Contemporary and traditionalist sensibilities in equal measures are how she keeps the mood going on. A recent style is a perfect example of this perpetual versatile understated elegance that Kirti carries about her all the time. A blue cotton saree teamed with a cropped, loose black blouse was how she decided to woo us.
China's market regulator and other government departments have launched an exercise focused on e-commerce, with plans to crack down on areas such as unfair competition and the illegal trading of counterfeits or wildlife, state news agency Xinhua said. The operation will run until December and will also look into areas such as livestreaming, which has in the past two years become a popular sales channel in China, Xinhua said on Saturday, referring to a recently issued notice from the State Administration of Market Supervision and other departments.
Dozens of hostels across Bangkok have thrown open their doors to give weary demonstrators a refuge as anti establishment rallies continue to grip the city. This 23-year-old, who wants to be known as Aom, founded the Hostel Provider Group. "It all started in the morning of October 15 when the government cracked down on the protest at the government house. I felt bad for those who didn't have a place to stay because to me no one should endure this kind of thing. So I posted on my Twitter offering free hostel stay with my own money that I collected from selling things online." Since mid-July, protesters have called for Prime Minister Prayuth Chan-ocha to resign and to challenge a longstanding taboo by demanding reform of the monarchy. At times facing water cannon and playing cat and mouse with police in sweltering conditions many demonstrators have been sleeping on the street. There is plenty of space in hotels and hostels across the usually bustling city, which is now virtually empty of foreign tourists since authorities shut Thailand's borders to most commercial flights. One hostel we spoke with said they had taken hundreds of protesters just themselves. Alongside a bed, protesters can receive three meals per day as well as transport to protests. "It shows that everyone wants democracy, everyone wants to support the protest and youth movement."