| 15.70% | % of Shares Held by All Insider |
| 83.65% | % of Shares Held by Institutions |
| 99.23% | % of Float Held by Institutions |
| 272 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Blackrock Inc. | 4,877,215 | Mar 30, 2019 | 13.31% | 279,513,191 |
| Vanguard Group, Inc. (The) | 3,405,422 | Mar 30, 2019 | 9.30% | 195,164,734 |
| State Street Corporation | 1,673,787 | Mar 30, 2019 | 4.57% | 95,924,732 |
| Redmile Group, LLC | 1,420,342 | Mar 30, 2019 | 3.88% | 81,399,800 |
| JP Morgan Chase & Company | 1,205,445 | Mar 30, 2019 | 3.29% | 69,084,052 |
| Perceptive Advisors Llc | 1,145,726 | Mar 30, 2019 | 3.13% | 65,661,557 |
| WS Management, LLP | 995,760 | Mar 30, 2019 | 2.72% | 57,067,005 |
| Renaissance Technologies, LLC | 869,741 | Mar 30, 2019 | 2.37% | 49,844,856 |
| FMR, LLC | 863,294 | Mar 30, 2019 | 2.36% | 49,475,379 |
| Price (T.Rowe) Associates Inc | 720,804 | Mar 30, 2019 | 1.97% | 41,309,277 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| iShares Core S&P Smallcap ETF | 1,850,063 | Jun 29, 2019 | 5.05% | 95,037,736 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,131,918 | Jun 29, 2019 | 3.09% | 58,146,627 |
| Vanguard Total Stock Market Index Fund | 863,173 | Dec 30, 2018 | 2.36% | 36,210,107 |
| Vanguard Small-Cap Index Fund | 831,194 | Dec 30, 2018 | 2.27% | 34,868,588 |
| iShares Russell 2000 ETF | 696,136 | Jun 29, 2019 | 1.90% | 35,760,506 |
| Price (T.Rowe) Health Sciences Fund | 520,195 | Jun 29, 2019 | 1.42% | 26,722,417 |
| Vanguard Small-Cap Growth Index Fund | 468,082 | Dec 30, 2018 | 1.28% | 19,636,039 |
| Fidelity Select Portfolios - Biotechnology | 459,408 | May 30, 2019 | 1.25% | 19,763,732 |
| iShares S&P Small Cap 600 Growth Index ETF | 455,199 | Jun 29, 2019 | 1.24% | 23,383,572 |
| Vanguard Extended Market Index Fund | 415,053 | Dec 30, 2018 | 1.13% | 17,411,473 |