SANTA CLARA, Calif. (AP) — Carson Wentz threw two TD passes and ran for another score to lead the Indianapolis Colts to a rain-soaked 30-18 victory over the San Francisco 49ers on Sunday night.
The Colts (3-4) overcame the wet conditions and an early nine-point deficit to win for the third time in four games following an 0-3 start to the season.
The 49ers (2-4) dropped their fourth straight game and remained winless at home for more than a year since beating the Rams last Oct. 18, 2020, as the return of starting quarterback Jimmy Garoppolo failed to provide any spark on a wet night.
Garoppolo threw for 181 yards, lost a fumble, threw two interceptions and struggled to push the ball downfield in his first game back after missing one game with a calf injury.
Wentz and the Colts were able to do just enough on offense thanks to three pass interference penalties for 97 yards and a productive game on the ground from Jonathan Taylor, who ran for 107 yards and a score.
Wentz threw an 11-yard TD pass to Mo Alie-Cox in the first quarter and then led two short TD drives following fumbles by San Francisco, leading to his 1-yard score late in the first half and Taylor's 5-yard run that made it 20-12 late in the third.
Garoppolo led a TD drive early in the fourth, cutting the deficit to 20-18 on a 14-yard throw to Deebo Samuel. But his 2-point try was batted down at the line.
The Colts then put it away by driving for a field goal and getting a 28-yard TD pass from Wentz to Michael Pittman Jr. on another short field after Xavier Rhodes intercepted Garoppolo.
IN THE SLOP
The driving rain storm had a big impact on the game, especially during a stretch midway through the second quarter.
Colts running back Nyheim Hines got wide open downfield on a third-down pass that slipped right through his hands.
Indianapolis then punted and Brandon Aiyuk muffed the ball before kicking it back nearly 20 yards into the end zone. He recovered it and it was ruled a touchback because he never had possession.
Wentz and Garoppolo both fumbled snaps that they recovered later in the quarter before Samuel lost a fumble for San Francisco at his own 28 on a perfect punchout by Darius Leonard.
That set up a 1-yard run by Wentz that gave the Colts a 13-12 halftime lead.
TAKE IT AWAY
The Niners came in with a league-low two takeaways but doubled that total in the first half.
Taylor fumbled on Indianapolis first play from scrimmage and Fred Warner recovered to set up a field goal by Joey Slye that made it 9-0.
Wentz then made an inexplicable decision early in the second quarter. As he was trying to run away from Nick Bosa, Wentz appeared to flip the ball forward right into Azeez Al-Shaair's hands. It was ruled a fumble.
Colts: CB BoPete Keyes (hamstring) left in the first half and didn't return.
49ers: LT Trent Williams was scratched after aggravating an ankle injury last week in practice. Rookie Jaylon Moore made his first career start in his place. ... S Jaquiski Tartt left with a knee injury.
Colts: Host Titans on Sunday.
49ers: Visit Chicago on Sunday.
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Josh Dubow, The Associated Press