The Blades have endured a miserable start, taking just one point from their opening eight matches, and are currently bottom of the division.
Their problems have been compounded by a shortage of firepower up front, with neither Rhian Brewster nor Oli McBurnie hitting the ground running.
READ MORE: Every Premier League fixture and table
West Ham are in much higher spirits, though, in spite of a tumultuous transfer window. The Hammers have negotiated a torrid run of fixtures, collecting 11 points, and Michail Antonio has returned to training over the international break.
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When is the match?
The game kicks off on Sunday 22 November at Bramall Lane.
What time is kick-off?
Kick-off is 2pm GMT.
How can I watch it?
The match is being broadcast on Sky Sports Main Event and Sky Sports Premier League. Subscribers can also stream the game live via the Sky Go app.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
READ MORE: West Ham losing £2m per match without fans
Sheffield United: Ramsdale, Basham, Egan, Ampadu, Baldock, Berge, Norwood, Fleck, Lowe, McBurnie, McGoldrick
West Ham: Fabianski, Balbuena, Ogbonna, Cresswell, Coufal, Rice, Soucek, Masuaku, Bowen, Fornals, Haller
What are the odds?
Sheffield United: 12/5
West Ham: 5/4
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League. Terms: Min £10 Same Game Multi bet on any EPL match this Fri - Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.