The Foxes’ 4-2 defeat to Newcastle means Jurgen Klopp’s side can go six points behind Leicester with a game in hand, if they can find a route to victory against Saints here.
Winning games on home soil has been a real issue for Liverpool however, with just one league triumph at Anfield since mid-December - with stoppage-time points dropped against Newcastle last time out being a case in point.
Last season’s champions must become more ruthless in the final weeks of the campaign if they want to keep the pressure on the teams above them, while Southampton could also do with a late revival to avoid the year being a real disappointment.
Their FA Cup semi-final exit effectively heralded the end of their season, with just two wins in their last 16 Premier League games leaving them floundering in the bottom half of the table. Follow our live coverage of Liverpool against Southampton below.