While the fixture is, of course, one of the most iconic in world football, Messi’s departure over the course of the summer raised questions about the star quality left in LaLiga.
How valid they are is clearly up for debate given both Barcelona and Real Madrid are capable of fielding teams most clubs around the world would envy, but the notion of the biggest game in Spain without the two players who defined an era in the division is certainly one that could take some getting used to.
That’s not to say it won’t be fascinating, however.
Considering the drama associated with any meeting of two of the biggest institutions in world football, as well as the problems Barcelona are currently enduring, it promises to be another entertaining encounter.
Where to watch Barcelona vs Real Madrid
TV channel: The match will be broadcast live by La Liga TV (which you can access through Amazon Prime or Premier Sports) with a 3.15pm BST kick-off, and coverage starting at 1.00pm BST.
Live stream: Premier Sports and Amazon Prime subscribers will be able to watch the game online through either their websites or the Premier Player/Amazon Prime app.
Read our dedicated match preview here.