| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Franklin Resources, Inc | 5,670,570 | 7.70 | 4,536,456 | 2013-03-31 | | Vanguard Group, Inc. (The) | 3,557,151 | 4.83 | 2,845,720 | 2013-03-31 | | BlackRock Institutional Trust Company, N.A. | 2,220,221 | 3.02 | 1,776,176 | 2013-03-31 | | Capital Research Global Investors | 1,921,119 | 2.61 | 1,536,895 | 2013-03-31 | | Wellington Management Company, LLP | 1,804,690 | 2.45 | 1,443,752 | 2013-03-31 | | FMR, LLC | 1,591,477 | 2.16 | 1,273,181 | 2013-03-31 | | Palo Alto Investors, LLC | 11,224,495 | 15.25 | 8,979,596 | 2013-03-31 | | JP Morgan Chase & Company | 1,050,279 | 1.43 | 840,223 | 2013-03-31 | | P. Schoenfeld Asset Management | 1,042,436 | 1.42 | 833,948 | 2013-03-31 | | Chesapeake Partners Management Co Inc./Md | 823,242 | 1.12 | 658,593 | 2013-03-31 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Smallcap World Fund | 1,758,122 | 2.39 | 1,406,497 | 2013-03-31 | | Fidelity Select Portfolios - Biotechnology | 1,472,700 | 2.00 | 1,178,160 | 2013-03-31 | | Vanguard Small-Cap Index Fund | 1,202,827 | 1.63 | 1,262,968 | 2012-12-31 | | Vanguard Total Stock Market Index Fund | 1,006,733 | 1.37 | 1,057,069 | 2012-12-31 | | Templeton Global Opportunities Trust | 879,640 | 1.19 | 703,712 | 2013-03-31 | | Vanguard Small-Cap Growth Index Fund | 863,199 | 1.17 | 906,358 | 2012-12-31 | | Vanguard Extended Market Index Fund | 733,931 | 1.00 | 770,627 | 2012-12-31 | | iShares NASDAQ Biotechnology Index Fund | 594,684 | 0.81 | 475,747 | 2013-03-31 | | Bridgeway Funds Inc-Ultra Small Company Market Fund | 246,800 | 0.34 | 259,140 | 2012-12-31 | | Spartan Extended Market Index Fund | 212,410 | 0.29 | 169,928 | 2013-03-31 |
|
View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |