| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Wellington Management Company, LLP | 18,251,636 | 8.38 | 164,629,756 | 2012-12-31 | | Vanguard Group, Inc. (The) | 12,690,573 | 5.83 | 104,189,604 | 2013-03-31 | | BlackRock Fund Advisors | 6,814,603 | 3.13 | 55,947,890 | 2013-03-31 | | BlackRock Institutional Trust Company, N.A. | 6,091,762 | 2.80 | 50,013,366 | 2013-03-31 | | State Street Corporation | 6,051,773 | 2.78 | 49,685,056 | 2013-03-31 | | Oppenheimer Funds, Inc. | 6,000,000 | 2.76 | 49,260,000 | 2013-03-31 | | Deerfield Management | 5,348,220 | 2.46 | 43,908,886 | 2013-03-31 | | Capital World Investors | 5,000,000 | 2.30 | 45,100,000 | 2012-12-31 | | FMR LLC | 4,347,873 | 2.00 | 39,217,814 | 2012-12-31 | | Northern Trust Corporation | 3,032,659 | 1.39 | 24,898,130 | 2013-03-31 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Oppenheimer Global Opportunities Fund | 6,000,000 | 2.76 | 54,120,000 | 2012-12-31 | | American Funds Insurance Ser-Growth Fund | 5,000,000 | 2.30 | 41,050,000 | 2013-03-31 | | Fidelity Select Portfolios - Biotechnology | 3,753,744 | 1.72 | 30,818,238 | 2013-03-31 | | Vanguard Small-Cap Index Fund | 3,606,303 | 1.66 | 32,528,853 | 2012-12-31 | | iShares Russell 2000 Index Fund | 3,477,143 | 1.60 | 28,547,344 | 2013-03-31 | | Vanguard Total Stock Market Index Fund | 2,886,488 | 1.33 | 26,036,121 | 2012-12-31 | | SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,064,490 | 0.95 | 16,949,462 | 2013-03-31 | | Vanguard Extended Market Index Fund | 1,801,605 | 0.83 | 16,250,477 | 2012-12-31 | | Vanguard Small-Cap Growth Index Fund | 1,646,748 | 0.76 | 14,853,666 | 2012-12-31 | | iShares NASDAQ Biotechnology Index Fund | 1,482,515 | 0.68 | 12,171,448 | 2013-03-31 |
|
View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |
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