| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date |
Insider |
Shares |
Transaction |
Value* |
| 9-Jan-08 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
2,238 |
Purchase at $8.95 per share. |
$20,030 |
| 9-Jan-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
70,449 |
Purchase at $8.95 per share. |
$630,518 |
| 9-Jan-08 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
1,471 |
Purchase at $8.95 per share. |
$13,165 |
| 9-Jan-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
192 |
Purchase at $8.95 per share. |
$1,718 |
| 9-Jan-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
27,828 |
Purchase at $8.95 per share. |
$249,060 |
| 8-Jan-08 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
3,274 |
Purchase at $8.76 per share. |
$28,680 |
| 8-Jan-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
103,076 |
Purchase at $8.76 per share. |
$902,945 |
| 8-Jan-08 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
2,153 |
Purchase at $8.76 per share. |
$18,860 |
| 8-Jan-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
281 |
Purchase at $8.76 per share. |
$2,461 |
| 8-Jan-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
40,716 |
Purchase at $8.76 per share. |
$356,672 |
| 9-Nov-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
6,286 |
Purchase at $7.63 per share. |
$47,962 |
| 9-Nov-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
198,883 |
Purchase at $7.63 per share. |
$1,517,477 |
| 9-Nov-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
700 |
Purchase at $7.63 per share. |
$5,341 |
| 9-Nov-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
532 |
Purchase at $7.63 per share. |
$4,059 |
| 9-Nov-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
78,599 |
Purchase at $7.63 per share. |
$599,710 |
| 8-Nov-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
11,026 |
Purchase at $7.43 - $7.43 per share. |
$82,0002
|
| 8-Nov-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
348,917 |
Purchase at $7.43 - $7.43 per share. |
$2,592,0002
|
| 8-Nov-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
1,229 |
Purchase at $7.43 - $7.43 per share. |
$9,1312
|
| 8-Nov-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
934 |
Purchase at $7.43 - $7.43 per share. |
$6,9392
|
| 8-Nov-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
137,894 |
Purchase at $7.43 - $7.43 per share. |
$1,025,0002
|
| 7-Nov-07 |
SOLAND DANIEL B Officer
|
10,000 |
Purchase at $7.26 - $7.26 per share. |
$73,0002
|
| 7-Nov-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
8,821 |
Purchase at $7.27 - $7.27 per share. |
$64,0002
|
| 7-Nov-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
279,134 |
Purchase at $7.27 - $7.27 per share. |
$2,029,0002
|
| 7-Nov-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
983 |
Purchase at $7.27 - $7.27 per share. |
$7,1462
|
| 7-Nov-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
747 |
Purchase at $7.27 - $7.27 per share. |
$5,4302
|
| 7-Nov-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
110,315 |
Purchase at $7.27 - $7.27 per share. |
$802,0002
|
| 1-Nov-07 |
SOLAND DANIEL B Officer
|
15,000 |
Purchase at $8.31 - $8.31 per share. |
$125,0002
|
| 4-Sep-07 |
DE ROSEN MICHEL Officer
|
39,477 |
Option Exercise at $2.09 - $2.71 per share. |
N/A |
| 16-Aug-07 |
SOLAND DANIEL B Officer
|
15,000 |
Purchase at $8 - $8 per share. |
$120,0002
|
| 16-Aug-07 |
MILANO VINCENT Officer
|
4,000 |
Purchase at $8.04 - $8.22 per share. |
$33,0002
|
| 16-Aug-07 |
DE ROSEN MICHEL Officer
|
12,120 |
Purchase at $8.17 - $8.17 per share. |
$99,0002
|
| 15-Aug-07 |
CLAYPOOL WILLIAM D MD Director
|
10,000 |
Purchase at $8.30 - $8.38 per share. |
$83,0002
|
| 17-Apr-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
3,477 |
Sale at $15.43 - $15.45 per share. |
$54,0002
|
| 17-Apr-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
775 |
Sale at $15.43 - $15.45 per share. |
$12,0002
|
| 17-Apr-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
2,198 |
Sale at $15.43 - $15.45 per share. |
$34,0002
|
| 17-Apr-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
128,066 |
Sale at $15.43 - $15.45 per share. |
$1,977,0002
|
| 17-Apr-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
47,053 |
Sale at $15.43 - $15.45 per share. |
$726,0002
|
| 16-Apr-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
1,667 |
Sale at $15.44 - $15.54 per share. |
$26,0002
|
| 16-Apr-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
371 |
Sale at $15.44 - $15.54 per share. |
$5,7462
|
| 16-Apr-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
1,053 |
Sale at $15.44 - $15.54 per share. |
$16,0002
|
| 16-Apr-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
61,364 |
Sale at $15.44 - $15.54 per share. |
$951,0002
|
| 16-Apr-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
22,545 |
Sale at $15.44 - $15.54 per share. |
$349,0002
|
| 13-Apr-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
9,650 |
Sale at $15.30 - $15.32 per share. |
$148,0002
|
| 13-Apr-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
2,149 |
Sale at $15.30 - $15.32 per share. |
$33,0002
|
| 13-Apr-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
6,092 |
Sale at $15.30 - $15.32 per share. |
$93,0002
|
| 13-Apr-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
355,122 |
Sale at $15.30 - $15.32 per share. |
$5,437,0002
|
| 13-Apr-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
130,472 |
Sale at $15.30 - $15.32 per share. |
$1,998,0002
|
| 7-Feb-07 |
GLASER ROBERT Director
|
10,000 |
Option Exercise at $15.13 - $15.13 per share. |
$151,0002
|
| 7-Feb-07 |
GLASER ROBERT Director
|
10,000 |
Sale at $18 - $18.04 per share. |
$180,0002
|
| 30-Jan-07 |
GLASER ROBERT Director
|
2,500 |
Option Exercise at $15.13 - $15.13 per share. |
$38,0002
|
| 30-Jan-07 |
GLASER ROBERT Director
|
2,500 |
Sale at $17 - $17 per share. |
$43,0002
|
| 25-Jan-07 |
GLASER ROBERT Director
|
2,500 |
Option Exercise at $15.13 - $15.13 per share. |
$38,0002
|
| 25-Jan-07 |
GLASER ROBERT Director
|
2,500 |
Sale at $16 - $16 per share. |
$40,0002
|
| 6-Dec-06 |
DOYLE THOMAS F Officer
|
7,000 |
Option Exercise at $13 - $13 per share. |
$91,0002
|
| 6-Dec-06 |
DOYLE THOMAS F Officer
|
7,000 |
Sale at $14.92 - $15.1 per share. |
$105,0002
|
| 8-Sep-06 |
LEONE JOHN R Director
|
2,000 |
Purchase at $12.25 - $12.28 per share. |
$25,0002
|
| 9-May-06 |
DE ROSEN MICHEL Officer
|
10,100 |
Purchase at $9.82 - $9.85 per share. |
$99,0002
|
| 8-May-06 |
CLAYPOOL WILLIAM D MD Director
|
10,000 |
Purchase at $9.62 - $9.65 per share. |
$96,0002
|
| 28-Feb-06 |
BAKER BIOTECH CAPITAL II (GP), LLC Beneficial Owner (10% or more)
|
111,194 |
Sale at $19.90 - $21.81 per share. |
$2,319,0002
|
| 28-Feb-06 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
122,854 |
Sale at $19.90 - $21.81 per share. |
$2,562,0002
|
| 28-Feb-06 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
24,259 |
Sale at $19.90 - $21.81 per share. |
$506,0002
|
| 28-Feb-06 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
11,868 |
Sale at $19.90 - $21.81 per share. |
$248,0002
|
| 28-Feb-06 |
BAKER BIOTECH CAPITAL II (Z) (GP), LLC Beneficial Owner (10% or more)
|
15,707 |
Sale at $19.90 - $21.81 per share. |
$328,0002
|
| 28-Feb-06 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
97,439 |
Sale at $19.90 - $21.81 per share. |
$2,032,0002
|
| 28-Feb-06 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
21,445 |
Sale at $19.90 - $21.81 per share. |
$447,0002
|
| 28-Feb-06 |
BAKER BIOTECH CAPITAL III (Z) (GP), LLC Beneficial Owner (10% or more)
|
18,855 |
Sale at $19.90 - $21.81 per share. |
$393,0002
|
| 27-Feb-06 |
BAKER BIOTECH CAPITAL II (GP), LLC Beneficial Owner (10% or more)
|
112,218 |
Sale at $21.58 - $21.74 per share. |
$2,431,0002
|
| 27-Feb-06 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
123,987 |
Sale at $21.58 - $21.74 per share. |
$2,686,0002
|
| 27-Feb-06 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
24,486 |
Sale at $21.58 - $21.74 per share. |
$530,0002
|
| 27-Feb-06 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
11,978 |
Sale at $21.58 - $21.74 per share. |
$259,0002
|
| 27-Feb-06 |
BAKER BIOTECH CAPITAL II (Z) (GP), LLC Beneficial Owner (10% or more)
|
15,851 |
Sale at $21.58 - $21.74 per share. |
$343,0002
|
| 27-Feb-06 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
98,334 |
Sale at $21.58 - $21.74 per share. |
$2,130,0002
|
| 27-Feb-06 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
21,633 |
Sale at $21.58 - $21.74 per share. |
$469,0002
|
| 27-Feb-06 |
BAKER BIOTECH CAPITAL III (Z) (GP), LLC Beneficial Owner (10% or more)
|
19,030 |
Sale at $21.58 - $21.74 per share. |
$412,0002
|
|
* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown.
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