| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date |
Insider |
Shares |
Transaction |
Value* |
| 9-Nov-09 |
QUART BARRY D Officer
|
10,000 |
Option Exercise at $3.90 per share. |
$39,000 |
| 28-Oct-09 |
MANHARD KIMBERLY Officer
|
2,500 |
Option Exercise at $3.90 per share. |
$9,750 |
| 28-Oct-09 |
MANHARD KIMBERLY Officer
|
2,500 |
Automatic Sale at $14.20 per share. |
$35,500 |
| 23-Oct-09 |
KRUEGER CHRISTOPHER W Officer
|
3,000 |
Option Exercise at $5.20 per share. |
$15,600 |
| 23-Oct-09 |
KRUEGER CHRISTOPHER W Officer
|
3,000 |
Automatic Sale at $15.25 per share. |
$45,750 |
| 12-Oct-09 |
FUCHS HENRY J Director
|
2,000 |
Option Exercise at $2.76 per share. |
$5,520 |
| 12-Oct-09 |
FUCHS HENRY J Director
|
2,000 |
Automatic Sale at $17.08 per share. |
$34,160 |
| 28-Sep-09 |
MANHARD KIMBERLY Officer
|
2,500 |
Option Exercise at $3.90 per share. |
$9,750 |
| 28-Sep-09 |
MANHARD KIMBERLY Officer
|
2,500 |
Automatic Sale at $19.10 per share. |
$47,750 |
| 23-Sep-09 |
KRUEGER CHRISTOPHER W Officer
|
3,000 |
Option Exercise at $5.20 per share. |
$15,600 |
| 23-Sep-09 |
KRUEGER CHRISTOPHER W Officer
|
3,000 |
Automatic Sale at $18.67 - $19.49 per share. |
$57,0002
|
| 10-Sep-09 |
FUCHS HENRY J Director
|
2,000 |
Option Exercise at $2.76 per share. |
$5,520 |
| 10-Sep-09 |
FUCHS HENRY J Director
|
2,000 |
Automatic Sale at $19.31 per share. |
$38,620 |
| 28-Aug-09 |
MANHARD KIMBERLY Officer
|
2,500 |
Option Exercise at $3.90 per share. |
$9,750 |
| 28-Aug-09 |
MANHARD KIMBERLY Officer
|
2,500 |
Automatic Sale at $18.39 per share. |
$45,975 |
| 24-Aug-09 |
KRUEGER CHRISTOPHER W Officer
|
3,000 |
Option Exercise at $5.20 per share. |
$15,600 |
| 24-Aug-09 |
KRUEGER CHRISTOPHER W Officer
|
5,061 |
Automatic Sale at $19 per share. |
$96,159 |
| 14-Aug-09 |
BECK JOHN W Officer
|
2,500 |
Option Exercise at $5.85 per share. |
$14,625 |
| 14-Aug-09 |
BECK JOHN W Officer
|
2,500 |
Automatic Sale at $20.15 per share. |
$50,375 |
| 13-Aug-09 |
QUART BARRY D Officer
|
10,000 |
Option Exercise at $3.90 per share. |
$39,000 |
| 11-Aug-09 |
QUART BARRY D Officer
|
25,000 |
Option Exercise at $3.90 per share. |
$97,500 |
| 11-Aug-09 |
QUART BARRY D Officer
|
25,000 |
Automatic Sale at $19.33 per share. |
$483,249 |
| 10-Aug-09 |
FUCHS HENRY J Director
|
2,000 |
Option Exercise at $2.76 per share. |
$5,520 |
| 10-Aug-09 |
FUCHS HENRY J Director
|
2,000 |
Automatic Sale at $19.85 per share. |
$39,700 |
| 27-May-09 |
QUART BARRY D Officer
|
10,000 |
Disposition (Non Open Market) at $0 per share. |
N/A |
| 27-May-09 |
QUART BARRY D Officer
|
2,500 |
Acquisition (Non Open Market) at $0 per share. |
N/A |
| 20-May-09 |
KRUEGER CHRISTOPHER W Officer
|
22,498 |
Option Exercise at $5.20 per share. |
$116,989 |
| 20-May-09 |
KRUEGER CHRISTOPHER W Officer
|
24,998 |
Sale at $14.81 - $15.27 per share. |
$376,0002
|
| 20-May-09 |
POYHONEN JOHN Director
|
3,000 |
Option Exercise at $5.85 per share. |
$17,550 |
| 20-May-09 |
POYHONEN JOHN Director
|
3,000 |
Sale at $15 per share. |
$45,000 |
| 20-May-09 |
BECK JOHN W Officer
|
5,000 |
Option Exercise at $5.85 per share. |
$29,250 |
| 20-May-09 |
BECK JOHN W Officer
|
5,000 |
Sale at $14.97 per share. |
$74,850 |
| 20-May-09 |
REMINGTON JACK Director
|
27,500 |
Option Exercise at $4.08 - $5.85 per share. |
N/A |
| 20-May-09 |
REMINGTON JACK Director
|
27,500 |
Sale at $14.95 per share. |
$411,125 |
| 19-May-09 |
KRUEGER CHRISTOPHER W Officer
|
2,502 |
Option Exercise at $5.20 per share. |
$13,010 |
| 19-May-09 |
KRUEGER CHRISTOPHER W Officer
|
2,502 |
Sale at $15.27 per share. |
$38,205 |
| 19-May-09 |
QUART BARRY D Officer
|
30,000 |
Option Exercise at $3.90 per share. |
$117,000 |
| 19-May-09 |
QUART BARRY D Officer
|
25,000 |
Sale at $14.90 - $16.3 per share. |
$390,0002
|
| 19-May-09 |
MANHARD KIMBERLY Officer
|
25,000 |
Option Exercise at $3.90 per share. |
$97,500 |
| 19-May-09 |
MANHARD KIMBERLY Officer
|
21,300 |
Sale at $15.05 per share. |
$320,565 |
| 19-May-09 |
POYHONEN JOHN Director
|
5,000 |
Option Exercise at $5.85 per share. |
$29,250 |
| 19-May-09 |
POYHONEN JOHN Director
|
5,000 |
Sale at $15.34 per share. |
$76,700 |
| 23-Jan-09 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
28,066 |
Disposition (Non Open Market) at $0 per share. |
N/A |
| 19-Dec-08 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
3,990 |
Purchase at $11.14 per share. |
$44,448 |
| 19-Dec-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
184,780 |
Purchase at $11.14 per share. |
$2,058,449 |
| 19-Dec-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
184,780 |
Purchase at $11.14 per share. |
$2,058,449 |
| 19-Dec-08 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
16,093 |
Purchase at $11.14 per share. |
$179,276 |
| 19-Dec-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
589,169 |
Purchase at $11.14 per share. |
$6,563,342 |
| 19-Dec-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
820 |
Purchase at $11.14 per share. |
$9,134 |
| 17-Dec-08 |
TANG KEVIN C Director
|
156,652 |
Purchase at $11.14 per share. |
$1,745,103 |
| 22-Sep-08 |
QUART BARRY D Officer
|
5,000 |
Option Exercise at $3.90 per share. |
$19,500 |
| 17-Sep-08 |
TANG KEVIN C Director
|
5,700 |
Option Exercise at $0 per share. |
N/A |
| 3-Sep-08 |
QUART BARRY D Officer
|
15,000 |
Option Exercise at $3.90 per share. |
$58,500 |
| 29-May-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
1,218 |
Disposition (Non Open Market) at $0 per share. |
N/A |
| 28-May-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
30,288 |
Disposition (Non Open Market) at $0 per share. |
N/A |
| 7-May-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
331,452 |
Acquisition (Non Open Market) |
N/A |
| 7-May-08 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
42,089 |
Acquisition (Non Open Market) |
N/A |
| 7-May-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
57,873 |
Acquisition (Non Open Market) |
N/A |
| 7-May-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
294,624 |
Acquisition (Non Open Market) |
N/A |
| 7-May-08 |
TANG KEVIN C Director
|
852,308 |
Acquisition (Non Open Market) |
N/A |
| 17-Apr-08 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
898 |
Purchase at $13.28 per share. |
$11,925 |
| 17-Apr-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
27,982 |
Purchase at $13.28 per share. |
$371,600 |
| 17-Apr-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
76 |
Purchase at $13.28 per share. |
$1,009 |
| 17-Apr-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
11,044 |
Purchase at $13.28 per share. |
$146,664 |
| 8-Apr-08 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
753 |
Purchase at $13.28 per share. |
$9,999 |
| 4-Apr-08 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
9,937 |
Purchase at $13.28 per share. |
$131,963 |
| 4-Apr-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
313,169 |
Purchase at $13.28 per share. |
$4,158,884 |
| 4-Apr-08 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
76,141 |
Purchase at $13.28 per share. |
$1,011,152 |
| 9-Jan-08 |
ANDREEFF DANE Beneficial Owner (10% or more)
|
277 |
Purchase at $15.94 per share. |
$4,415 |
| 31-Dec-07 |
ANDREEFF DANE Beneficial Owner (10% or more)
|
4,200 |
Purchase at $15.16 - $15.19 per share. |
$64,0002
|
| 26-Dec-07 |
ANDREEFF DANE Beneficial Owner (10% or more)
|
8,100 |
Purchase at $15.18 per share. |
$122,958 |
| 19-Dec-07 |
14159 CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
23,968 |
Purchase at $13.25 per share. |
$317,576 |
| 19-Dec-07 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
754,519 |
Purchase at $13.25 per share. |
$9,997,376 |
| 19-Dec-07 |
BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
15,754 |
Purchase at $13.25 per share. |
$208,740 |
| 19-Dec-07 |
BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
2,059 |
Purchase at $13.25 per share. |
$27,281 |
| 19-Dec-07 |
BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more)
|
298,040 |
Purchase at $13.25 per share. |
$3,949,030 |
| 19-Dec-07 |
TANG KEVIN C Director
|
37,731 |
Purchase at $13.25 per share. |
$499,935 |
| 13-Dec-07 |
HICKEY DENIS Officer
|
4,200 |
Sale at $12.75 - $13 per share. |
$54,0002
|
| 6-Dec-07 |
TANG KEVIN C Director
|
14,000 |
Purchase at $12.75 per share. |
$178,500 |
| 5-Dec-07 |
REMINGTON JACK Director
|
15,834 |
Option Exercise at $2.76 - $3.5 per share. |
N/A |
| 5-Dec-07 |
REMINGTON JACK Director
|
15,834 |
Sale at $11.30 - $11.49 per share. |
$180,0002
|
| 5-Dec-07 |
FUCHS HENRY J Director
|
2,899 |
Option Exercise at $2.76 per share. |
$8,001 |
| 5-Dec-07 |
TANG KEVIN C Director
|
39,000 |
Purchase at $11.78 - $11.78 per share. |
$459,0002
|
| 4-Dec-07 |
FUCHS HENRY J Director
|
80,208 |
Option Exercise at $2.76 - $2.76 per share. |
$221,0002
|
| 4-Dec-07 |
FUCHS HENRY J Director
|
83,107 |
Sale at $10.78 - $10.78 per share. |
$896,0002
|
| 4-Dec-07 |
TANG KEVIN C Director
|
55,850 |
Purchase at $10.76 - $10.81 per share. |
$602,0002
|
| 30-Nov-07 |
ANDREEFF DANE Beneficial Owner (10% or more)
|
1,594 |
Purchase at $13.20 per share. |
$21,040 |
| 28-Nov-07 |
ANDREEFF DANE Beneficial Owner (10% or more)
|
17,000 |
Purchase at $11.16 - $11.16 per share. |
$190,0002
|
|
* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown.
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