| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date |
Insider |
Shares |
Transaction |
Value* |
| 26-Jan-09 |
NADER FRANCOIS Officer
|
20,000 |
Acquisition (Non Open Market) at $0 per share. |
N/A |
| 22-Sep-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
283,200 |
Sale at $8.72 per share. |
$2,469,504 |
| 19-Sep-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
191,600 |
Sale at $8.55 per share. |
$1,638,180 |
| 17-Apr-08 |
NADER FRANCOIS Officer
|
21,534 |
Option Exercise at $0 per share. |
N/A |
| 17-Apr-08 |
NADER FRANCOIS Officer
|
7,623 |
Disposition (Non Open Market) at $3.60 per share. |
$27,442 |
| 19-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
3,400 |
Purchase at $3.90 per share. |
$13,260 |
| 17-Mar-08 |
NADER FRANCOIS Officer
|
50,000 |
Acquisition (Non Open Market) at $0 per share. |
N/A |
| 17-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
45,500 |
Purchase at $3.80 per share. |
$172,900 |
| 17-Mar-08 |
COLES N ANTHONY Officer
|
62,572 |
Disposition (Non Open Market) at $3.85 per share. |
$240,902 |
| 17-Mar-08 |
COLES N ANTHONY Officer
|
135,000 |
Acquisition (Non Open Market) at $0 per share. |
N/A |
| 14-Mar-08 |
COLES N ANTHONY Officer
|
76,336 |
Acquisition (Non Open Market) at $0 per share. |
N/A |
| 14-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
100,000 |
Purchase at $3.84 per share. |
$384,000 |
| 13-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
8,300 |
Purchase at $3.77 per share. |
$31,291 |
| 12-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
38,600 |
Purchase at $3.82 per share. |
$147,452 |
| 11-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
53,900 |
Purchase at $3.71 per share. |
$199,969 |
| 10-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
126,000 |
Purchase at $3.73 per share. |
$469,980 |
| 7-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
146,100 |
Purchase at $3.81 per share. |
$556,641 |
| 6-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
4,336,115 |
Statement of Ownership |
N/A |
| 6-Mar-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more)
|
2,559,000 |
Statement of Ownership |
N/A |
|
* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown.
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