| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date |
Insider |
Shares |
Transaction |
Value* |
| 8-Jan-10 |
FRIEDMAN STEVEN M. Officer
|
22,000 |
Sale at $10.90 per share. |
$239,800 |
| 24-Sep-09 |
14159 CAPITAL (GP), LLC Director
|
101,506 |
Acquisition (Non Open Market) at $6.75 per share. |
$685,165 |
| 24-Sep-09 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
1,848,200 |
Acquisition (Non Open Market) at $6.75 per share. |
$12,475,350 |
| 24-Sep-09 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
50,294 |
Acquisition (Non Open Market) at $6.75 per share. |
$339,484 |
| 9-Mar-09 |
FRIEDMAN PAUL A Officer
|
9,400 |
Purchase at $2.10 per share. |
$19,740 |
| 6-Mar-09 |
FRIEDMAN PAUL A Officer
|
10,600 |
Purchase at $2.10 per share. |
$22,260 |
| 5-Mar-09 |
FRIEDMAN PAUL A Officer
|
8,840 |
Purchase at $2.20 per share. |
$19,448 |
| 5-Mar-09 |
14159 CAPITAL (GP), LLC Director
|
312 |
Purchase at $2.16 per share. |
$673 |
| 5-Mar-09 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
11,232 |
Purchase at $2.16 per share. |
$24,261 |
| 5-Mar-09 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
64 |
Purchase at $2.16 per share. |
$138 |
| 5-Mar-09 |
BAKER BROS. CAPITAL (GP), LLC Director
|
5 |
Purchase at $2.16 per share. |
$10 |
| 5-Mar-09 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
1,248 |
Purchase at $2.16 per share. |
$2,695 |
| 3-Mar-09 |
FRIEDMAN PAUL A Officer
|
11,160 |
Purchase at $2.20 per share. |
$24,552 |
| 3-Mar-09 |
14159 CAPITAL (GP), LLC Director
|
264 |
Purchase at $2.14 per share. |
$564 |
| 3-Mar-09 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
9,524 |
Purchase at $2.14 per share. |
$20,381 |
| 3-Mar-09 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
98 |
Purchase at $2.14 per share. |
$209 |
| 3-Mar-09 |
BAKER BROS. CAPITAL (GP), LLC Director
|
5 |
Purchase at $2.14 per share. |
$10 |
| 3-Mar-09 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
2,199 |
Purchase at $2.14 per share. |
$4,705 |
| 2-Mar-09 |
14159 CAPITAL (GP), LLC Director
|
927 |
Purchase at $2.14 - $2.17 per share. |
$1,9972
|
| 2-Mar-09 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
33,364 |
Purchase at $2.14 - $2.17 per share. |
$72,0002
|
| 2-Mar-09 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
343 |
Purchase at $2.14 - $2.17 per share. |
$7392
|
| 2-Mar-09 |
BAKER BROS. CAPITAL (GP), LLC Director
|
17 |
Purchase at $2.14 - $2.17 per share. |
$362
|
| 2-Mar-09 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
7,701 |
Purchase at $2.14 - $2.17 per share. |
$17,0002
|
| 27-Jan-09 |
FRIEDMAN STEVEN M. Officer
|
54,389 |
Statement of Ownership |
N/A |
| 19-Dec-08 |
14159 CAPITAL (GP), LLC Director
|
7,772 |
Purchase at $3.60 - $3.62 per share. |
$28,0002
|
| 19-Dec-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
284,546 |
Purchase at $3.60 - $3.62 per share. |
$1,027,0002
|
| 19-Dec-08 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
1,927 |
Purchase at $3.60 - $3.62 per share. |
$6,9562
|
| 19-Dec-08 |
BAKER BROS. CAPITAL (GP), LLC Director
|
1,454 |
Purchase at $3.60 - $3.62 per share. |
$5,2482
|
| 19-Dec-08 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
89,241 |
Purchase at $3.60 - $3.62 per share. |
$322,0002
|
| 18-Dec-08 |
14159 CAPITAL (GP), LLC Director
|
6,252 |
Purchase at $3.56 - $3.6 per share. |
$22,0002
|
| 18-Dec-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
228,972 |
Purchase at $3.56 - $3.6 per share. |
$820,0002
|
| 18-Dec-08 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
1,628 |
Purchase at $3.56 - $3.6 per share. |
$5,8282
|
| 18-Dec-08 |
BAKER BROS. CAPITAL (GP), LLC Director
|
133 |
Purchase at $3.56 - $3.6 per share. |
$4762
|
| 18-Dec-08 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
68,463 |
Purchase at $3.56 - $3.6 per share. |
$245,0002
|
| 17-Dec-08 |
14159 CAPITAL (GP), LLC Director
|
6,061 |
Purchase at $3.15 - $3.33 per share. |
$20,0002
|
| 17-Dec-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
221,814 |
Purchase at $3.15 - $3.33 per share. |
$719,0002
|
| 17-Dec-08 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
1,501 |
Purchase at $3.15 - $3.33 per share. |
$4,8632
|
| 17-Dec-08 |
BAKER BROS. CAPITAL (GP), LLC Director
|
309 |
Purchase at $3.15 - $3.33 per share. |
$1,0012
|
| 17-Dec-08 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
69,566 |
Purchase at $3.15 - $3.33 per share. |
$225,0002
|
| 21-Nov-08 |
METCALF BRIAN W Officer
|
5,000 |
Purchase at $2.17 - $2.2 per share. |
$11,0002
|
| 20-Nov-08 |
CHARDONNET LAURENT Other
|
8,000 |
Purchase at $2.70 - $2.71 per share. |
$22,0002
|
| 20-Nov-08 |
FRIEDMAN PAUL A Officer
|
13,000 |
Purchase at $2.55 per share. |
$33,150 |
| 20-Nov-08 |
SCHRECK PATRICIA A Officer
|
2,500 |
Purchase at $2.44 per share. |
$6,100 |
| 20-Nov-08 |
HASTINGS DAVID C Officer
|
4,000 |
Purchase at $2.36 per share. |
$9,440 |
| 15-Oct-08 |
FRIEDMAN PAUL A Officer
|
5,300 |
Purchase at $4.60 per share. |
$24,379 |
| 14-Oct-08 |
FRIEDMAN PAUL A Officer
|
4,700 |
Purchase at $5.34 - $5.35 per share. |
$25,0002
|
| 31-Jul-08 |
14159 CAPITAL (GP), LLC Director
|
27,724 |
Purchase at $9 per share. |
$249,516 |
| 31-Jul-08 |
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director
|
864,092 |
Purchase at $9 per share. |
$7,776,828 |
| 31-Jul-08 |
BAKER / TISCH CAPITAL (GP), LLC Director
|
4,997 |
Purchase at $9 per share. |
$44,973 |
| 31-Jul-08 |
BAKER BROS. CAPITAL (GP), LLC Director
|
1,539 |
Purchase at $9 per share. |
$13,851 |
| 31-Jul-08 |
BAKER BIOTECH CAPITAL (GP), LLC Director
|
201,648 |
Purchase at $9 per share. |
$1,814,832 |
|
* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown.
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