| Insider Transactions Reported - Last Two Years |
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| Date | Insider | Shares | Type | Transaction | Value* |
|---|
| 2007-11-05 | MPM BIOVENTURES II QP LPBeneficial Owner (10% or more) | 3,828,319 | Indirect | Disposition (Non Open Market) | N/A | | 2007-11-05 | STILL TIMOTHY IOfficer | 75,832 | Direct | Disposition (Non Open Market) | N/A | | 2007-11-05 | MERSELIS JAMES DOfficer | 50,000 | Direct | Disposition (Non Open Market) | N/A | | 2007-10-17 | STILL TIMOTHY IOfficer | 75,832 | Direct | Option Exercise at $0.80 per share. | 60,665 | | 2007-09-12 | MPM BIOVENTURES II QP LPBeneficial Owner (10% or more) | 174,800 | Indirect | Sale at $12.79 per share. | 2,235,692 | | 2007-09-12 | WHEELER KURTDirector | 174,800 | Indirect | Sale at $12.79 per share. | 2,235,692 | | 2007-09-11 | MPM BIOVENTURES II QP LPBeneficial Owner (10% or more) | 300,600 | Indirect | Sale at $12.75 per share. | 3,832,650 | | 2007-09-11 | WHEELER KURTDirector | 300,600 | Indirect | Sale at $12.75 per share. | 3,832,650 | | 2007-02-21 | AYERS GREGORY MDirector | 1,000 | Indirect | Sale at $5.75 per share. | 5,750 | | 2007-02-20 | AYERS GREGORY MDirector | 4,600 | Indirect | Sale at $5.75 per share. | 26,450 | | 2007-02-14 | AYERS GREGORY MDirector | 1,585 | Indirect | Sale at $5.75 per share. | 9,113 | | 2007-02-11 | ULRICH ROBERT DDirector | 7,500 | Indirect | Sale at $5.63 per share. | 42,225 | | 2007-02-08 | AYERS GREGORY MDirector | 2,000 | Direct | Sale at $5.55 - $5.7 per share. | 11,0002 | | 2007-02-07 | AYERS GREGORY MDirector | 23,388 | Direct | Sale at $5 - $5.35 per share. | 121,0002 | | 2007-02-06 | AYERS GREGORY MDirector | 9,400 | Direct | Sale at $4.90 - $5.05 per share. | 47,0002 | | 2007-02-05 | AYERS GREGORY MDirector | 35,000 | Direct | Option Exercise at $0.80 per share. | 28,000 | | 2007-02-05 | AYERS GREGORY MDirector | 600 | Direct | Sale at $4.95 per share. | 2,970 | | 2006-12-11 | NEW ENTERPRISE ASSOCIATES 12, LIMITED PARTNERSHIPBeneficial Owner (10% or more) | 1,772,151 | Direct | Statement of Ownership | N/A | | 2006-12-11 | NEW ENTERPRISE ASSOCIATES 12, LIMITED PARTNERSHIPBeneficial Owner (10% or more) | 1,772,151 | Direct | Statement of Ownership | N/A | | 2006-11-01 | DIPPEL WILLIAMOfficer | N/A | Direct | Statement of Ownership | N/A | | 2006-10-22 | MERSELIS JAMES DOfficer | 50,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 2006-09-17 | SANGSTER GORDONOfficer | N/A | Direct | Statement of Ownership | N/A | | 2006-06-13 | ULRICH ROBERT DDirector | 15,200 | Indirect | Sale at $5.47 per share. | 83,144 | | 2006-04-24 | SCHLOSS HARVEYDirector | N/A | Direct | Statement of Ownership | N/A |
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| Data provided by EDGAR Online |
* = Where indicated, some values are estimates. 1= Potential proceeds estimated by the filer. 2= Estimated based on the average of multiple prices reported. 3= Multiple dates reported. Most recent date shown.
Currency in CAD.
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